The ongoing beef between New York Giants safety Landon Collins and rookie cornerback Eli Apple is getting much more volatile.

Collins called Apple “a cancer” during an interview with Bob Wischusen on “The Michael Kay Show” on 98.7 ESPN New York on Tuesday.

Collins was responding to a question about what changes should be made to the Giants’ defensive backfield next year when he took his shot at Apple.

“There’s only just one corner that … needs to grow, and we all know who that is,” said Collins, one of the more popular players in the locker room. “That would be the only person I would change out of our secondary group. Besides, the other two guys, [Rodgers-Cromartie] and [Jenkins], I love those two guys. They play hard. They love what they do.

“But that first pick … he’s a cancer.”

Things have gotten heated between the two as Collins reportedly had to be restrained from confronting Apple in the past few weeks, according to a report by NJ Advance Media.

Collins, who was selected to the Pro Bowl as a starter, was placed on injured reserve Tuesday with a fractured forearm.

Collins talked about his emotional response to the injury.

“I don’t remember the last time I even cried,” Collins said. “As soon as I saw the picture up on the X-ray, I just broke down. I couldn’t hold in. I broke down.”